Does Tramadol Make You Tired?

Tramadol is a commonly prescribed painkiller, especially for people dealing with moderate to severe pain that doesn’t respond well to over-the-counter options. But if you’ve been prescribed Tramadol, or are considering taking it, you might be wondering about its side effects. One of the most frequent questions people ask is: Does Tramadol make you tired?

Before we get into that, it’s helpful to understand what Tramadol actually is.

In the UK, Tramadol is classified as a Class C controlled drug and is typically prescribed as an analgesic (pain reliever). And, as a class C drug, it is regulated under UK law due to its potential for misuse, but it is still recognised for its medical use in pain management.

So, how does Tramadol affect your energy levels, and why might it make you feel drowsy or fatigued? Are there any other side effects worth knowing about? Find out what you need to know in this article.

What is Tramadol?

Tramadol is a medicine classified as an opioid and is taken orally, but it may sometimes be administered intravenously in a hospital environment. It’s not as potent as morphine, but it does have a very strong reaction in the body.

The science behind Tramadol involves modulating the release of nociceptive neurotransmitters, including dopamine, acetylcholine, and norepinephrine. This inhibits pain and causes relief from it, as well as causing relaxation within the entire body.

Tramadol causes reactions within the body and also causes suppression. Medicine affects the body in various ways. For example, tramadol, like other medicines, can influence neurotransmitter levels, metabolism, and side effects, so it is important to monitor how this medicine affects each individual.

Much of the pain relief is caused by the blockade of norepinephrine and serotonin reuptake in the central nervous system. This prevents the transmission of pain, which eases pain effectively.

Does Tramadol Make You Tired?

Yes, it can.

Tramadol is known to cause drowsiness, tiredness, and even extreme fatigue in some people. In fact, the NHS says feeling very tired is a common side effect. These effects usually last between 4 to 6 hours for immediate-release tablets, but can extend up to 12 to 24 hours when using extended-release formulations.

Higher doses increase the likelihood and severity of side effects like sleepiness, which is why it’s important to take only the prescribed amount. And, because of its sedative effects, it’s recommended that you avoid driving or operating heavy machinery while using tramadol.

It’s also important to be cautious if you consume alcohol while taking tramadol. Mixing the two can intensify drowsiness, impair your judgment, and worsen respiratory side effects.

Over time, your body may develop a tolerance, meaning you need higher doses for the same effect. This increases the risk of fatigue and other side effects, as well as potential dependence. Always follow your doctor’s instructions closely and let them know about any other medications you’re taking to avoid harmful interactions.

What Are the Other Known Side Effects of Tramadol?

Like many prescription painkillers, Tramadol carries a range of possible side effects. And although not everyone will experience every single one of them, and they can fade over time as your body adjusts, it’s important to know what to look out for. Especially if you’re new to the medication or taking other drugs alongside it.

Drowsiness and Fatigue

As we’ve highlighted, one of the most well-known side effects of Tramadol is tiredness or drowsiness. This sedative effect is why it’s often advised not to drive or operate heavy machinery after taking it. Tramadol acts on the brain’s opioid receptors and can slow down nervous system activity, leading to a heavy, sluggish feeling. In some cases, people describe feeling “drugged” or mentally foggy. Long-term use may worsen fatigue, especially if higher doses are required due to tolerance.

Dizziness and Lightheadedness

Feeling dizzy or lightheaded is a common side effect of Tramadol, especially when standing up quickly (a condition known as orthostatic hypotension). This happens because Tramadol can lower blood pressure and alter how the brain processes signals from the body. If you notice frequent dizziness, especially with fainting or blurred vision, it’s essential to consult your doctor.

Nausea and Vomiting

Many people experience nausea when they first begin taking Tramadol. This is because the drug affects the central nervous system and the gastrointestinal tract. Nausea can range from mild queasiness to severe vomiting, and it often improves with food or after a few days of regular use. In more persistent cases, your doctor may recommend anti-nausea medications or switching painkillers.

Constipation

Tramadol, like most opioids, can slow down the movement of the digestive tract, leading to constipation. This is one of the most common long-term side effects, and it can be uncomfortable if not managed properly. Staying hydrated, increasing fibre intake, and sometimes using a gentle laxative or stool softener can help alleviate this issue.

Insomnia and Sleep Disturbances

Interestingly, while Tramadol can make some people feel sleepy, others actually report difficulty sleeping. This may be due to how the drug interacts with neurotransmitters like serotonin and norepinephrine, which are involved in mood and sleep regulation. Restlessness, vivid dreams, or nighttime wakefulness may occur, particularly in extended-release formulations.

Headache

Some users report headaches during the first few days or weeks of starting Tramadol. These can be tension-like or more intense, depending on the individual’s response to the drug. Headaches might also stem from dehydration, medication interactions, or withdrawal effects between doses.

Blurred Vision

Though less common, Tramadol can cause temporary changes in eyesight, including blurred vision or difficulty focusing. This is likely linked to its effect on the central nervous system. If this side effect persists or worsens, medical advice should be sought to rule out more serious issues.

Irregular or Rapid Heartbeat

Tramadol may cause cardiovascular symptoms like heart palpitations or an irregular heartbeat in some people. This is more likely in individuals with pre-existing heart conditions or those taking other medications that affect heart rhythm.

If you do happen to notice fluttering, pounding, or skipped heartbeats, you should seek medical attention promptly.

Breathing Problems

At higher doses or when combined with other depressants (like alcohol or benzodiazepines), Tramadol can suppress the respiratory system. This may lead to shallow, slow, or irregular breathing, especially during sleep. People with respiratory issues like asthma, COPD, or sleep apnea should use caution, as this side effect can be dangerous if left unmonitored.

Mental Health Effects

Tramadol can also affect your mood and mental state, which is why people taking certain types of antidepressants should not take Tramadol unless they’ve been authorised to do so by a doctor.

Some individuals experience anxiety, confusion, mood swings, or even hallucinations. In rare cases, it has been linked to suicidal thoughts or behaviours. If you or someone you know is experiencing significant changes in mood or behaviour after starting Tramadol, it’s vital to get help right away.

Withdrawal Symptoms

Stopping Tramadol suddenly can lead to withdrawal symptoms, especially after long-term use. These may include sweating, irritability, muscle aches, insomnia, nausea, and even flu-like symptoms. Tapering off the drug gradually under medical supervision is the safest way to avoid or lessen withdrawal effects.

Allergic Reactions and Interactions

An allergic reaction to Tramadol is considered very rare. Symptoms of an allergic reaction to tramadol may include:

• Hives
• Itching
• Swelling of the face or throat
• Difficulty breathing.

In rare cases, a severe allergic reaction called anaphylaxis can occur, which is life threatening and requires immediate medical attention. If you notice any signs of an allergic reaction while taking tramadol, call your doctor or seek emergency help right away.

Tramadol can also interact with other medications, which may increase the risk of serious side effects. For example, combining tramadol with certain antidepressants or other opioids can raise the risk of a condition called serotonin syndrome, which is a potentially dangerous buildup of serotonin in the body. Symptoms of serotonin syndrome include confusion, rapid heartbeat, muscle stiffness, and even hallucinations. Mixing tramadol with other medicines that depress the central nervous system, such as antihistamines or sedatives, can lead to shallow breathing, extreme drowsiness, or respiratory depression.

It’s also important to avoid drinking alcohol while taking tramadol, as this can intensify side effects like dizziness, drowsiness, and difficulty breathing. Always inform your doctor about all medications and supplements you are taking before starting tramadol, and never mix tramadol with other opioids or medicines without medical advice. If you experience any unusual symptoms or side effects, talk to your doctor or pharmacist promptly. Your safety is paramount, so don’t hesitate to call your doctor if you have any concerns about allergic reactions or interactions.

Can I Become Addicted to Tramadol?

Whilst it is one of the least potent opioids, as with any drug, abuse can lead to prescription drug addiction. Doctors prescribe tramadol based on individual needs and a thorough medical assessment to ensure safe and effective treatment. Addiction to any drug can cause a multitude of issues that can affect physical and mental health.

This can lead to the loss of your job, difficulties within relationships, and even money troubles. It must be known that long-term abuse or overdose can cause acute liver failure. It can damage organs and cause lasting physical issues. Addiction can happen more easily than you think.

Tramadol addiction only occurs when the drug is abused. Prescribed and controlled use of Tramadol is perfectly safe, but drug abuse can lead to dependence. Physical symptoms and behaviours that may be classed as red flags are:

• Pinpoint (very small) pupils
• Changes in appetite
• Nausea or vomiting
• Drowsiness
• Slurred speech
• Headaches
• Impaired coordination
• Social isolation/ neglect of work or relationships
• Seeing doctors more frequently for higher dosage prescriptions
• Mood changes or anger issues
• Extreme tiredness, exhaustion, and less interest in activities
• Potential thoughts about acquiring Tramadol illegally
• Financial problems

Taking Tramadol: How Much is Too Much?

You may first be prescribed Tramadol for a number of reasons. These include treating moderate to severe pain, for example after surgery or a serious injury. This may be as a result of a diagnosis where the pain is unbearable and medical assistance is required. The highest recommended dosage and prescription is no more than 400 mg per day.

The standard tablet form is around 50 mg. Anything that exceeds 400 mg may cause the first signs of tolerance to the drug. Tolerance then develops when the brain becomes accustomed to the presence of tramadol. If used incorrectly, any user will need to increase the dosage in order to feel the same effects. This tolerance will lead to an addiction and it may go unnoticed until the symptoms become debilitating for the user.

In the event of an opioid overdose, marked by symptoms like extreme sleepiness, trouble breathing, or loss of consciousness, seek medical attention immediately. Medications like naloxone can reverse the effects of an opioid overdose and save lives. If you or someone you know is at risk, don’t hesitate to call emergency services.

Remember, managing pain is a journey, and you don’t have to do it alone. Always follow your doctor’s instructions when taking tramadol or any other medication, and reach out for help if you have concerns about side effects, addiction, or alternative therapies. Your health and well-being are the top priority.

Alternatives and Therapies

If you are managing chronic pain or severe pain and are concerned about the side effects of tramadol, there are alternative options available. Non-opioid pain relievers, such as acetaminophen or ibuprofen, can be effective for mild to moderate pain and may have fewer risks of addiction or serious side effects. For those with more severe pain, your doctor may consider prescribing other opioids or combination medications, but these should always be used under close medical supervision.

Beyond medication, alternative therapies can play a significant role in pain management. Physical therapy, acupuncture, and cognitive-behavioural therapy are just a few approaches that can help relieve pain, improve mobility, and enhance your quality of life. These therapies can also help you develop coping strategies for living with chronic pain.

If you are taking tramadol and experience severe side effects, or if you are worried about becoming addicted to tramadol, talk to your doctor about other treatment options. Never stop taking tramadol suddenly, as this can lead to withdrawal symptoms such as nausea, sweating, anxiety, and trouble sleeping. Your doctor can help you gradually reduce your dose to minimise withdrawal symptoms and ensure a safer transition.

Getting the Help You Need

If you’re struggling with Tramadol misuse, reaching out for help is the first step toward recovery. Whilst this may seem impossible, there are plenty of routes to take.

Professional assistance and a rehab programme at one of our drug and alcohol rehab centres that are suited to your needs will give you the best chance of successful drug detox. Addiction can be cured and therefore you should consider reaching out to gain the help you need.

Here at Action Rehab we can offer you help, listen and guide you through your addiction toward a healthier future. Call us on 0151 268 6992 for any queries.

Posted on Thursday, July 24th, 2025 at 12:40 pm in Addiction, Latest News.